GLP-1 and Weight Management

GLP-1 peptides are a class of compounds that act on the receptors the gut uses to manage appetite and blood sugar. The newer ones reach past GLP-1 on its own: tirzepatide adds the GIP receptor, and retatrutide adds glucagon on top of that, which is why each generation has pushed weight-loss results higher in trials.
This range covers the main compounds studied for metabolic and weight-management work, including retatrutide, tirzepatide, tesofensine, AOD-9604 and 5-Amino-1MQ. For the science behind how they work, read our guide on what GLP-1 peptides are, plus the deeper dives on retatrutide and tirzepatide.